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Crohn’s Disease

Adult & Pediatric Crohn's Disease

IRT-103 in phase II clinical trials clinical trials showed

  • Effective
    • Remission in 67% with 43% true Mucosal healing with endoscopies
  • Safety
    • No-toxic side effect
    • 505B(2) pathway FDA
    • Immunomodulatory effect rather then a immunosupression drug

Cohn’s disease is a serious, chronic disease affecting the digestive system. Chronic means that the disease is long-term and persistent, usually lifelong. Crohn’s disease causes inflammation, most often in the small intestine (which has three parts: duodenum, jejunum, and ileum). The walls and lining of the affected areas become red and inflamed, leading to ulcers and bleeding. Crohn’s disease sometimes is named by referring to inflammation in the part of the intestine affected, such as Jejunoileitis, ileitis, ileocolitis, or colitis (when it involves the large intestine, also called the colon).

Crohn’s disease along with ulcerative colitis a similar illness is also called inflammatory bowel disease, or IBD. Crohn’s disease, can occur anywhere in the digestive tract, from mouth to the anus, attacks different sites in the intestine with areas of normal intestine in between, and affects the full thickness of the intestinal wall. Crohn’s and IBS go and go there are times when symptoms reappear or get worse (exacerbations or “flares”) and other periods when symptoms get better or go away altogether (“remission”).

Pilot & Phase 2 Pediatric & Adult Clinical Trials using LDN

Crohn’s disease causes many problems for people of all ages; it can be a challenge for children and teens. In addition to the often-painful symptoms, the disease can stunt growth, delay puberty, weaken the bones and can even cause death. Crohn’s disease symptoms may sometimes prevent a child from participating in enjoyable activities. The emotional and psychological issues of living with chronic disease can be especially difficult for both adults and children. It is estimated 1.4 million patients suffer from inflammatory bowel disease including some 140,000 children from birth to 18 years of age.

IBD_in_Children

While there’s no known cure for Crohn’s disease, therapies can greatly reduce its signs and symptoms and even bring about long-term remission, but most all of the treatments have major side effects.

Current treatment options are utilized to reduce the symptoms and provide relief from Diarrhea, Fever and Fatigue, Abdominal pain and cramping, bleeding, reduced appetite and weight loss, perianal disease, Other complications may occur outside the gastrointestinal tract and include anemia, skin rashes, arthritis, inflammation of the eye and fatigue, also commonly occurs and those with the disease are at greater risk of bowel cancer especially in younger patients.

Currently prescribed medications include Anti-inflammatory drugs to reduce inflammation, immuno-suppressants to get the immune response back under control, Antibiotics, pain medication and finally surgery.

While mild Crohn’s disease is typically treated with corticosteroids, more moderate to severe crohn’s disease is typically treated with immuno-suppressants. Long-term use of either corticosteroids or immuno-suppressants can cause serious complications, including diabetes, high blood pressure, elevated cholesterol and cataracts. This is a particularly important issue since the average age of patients who develop Crohn’s Disease is approximately 15 to 30 and severe side effects can be problematic.